Description

Methyl (4S)-(+)-2,2-Dimethyl-1,3-Dioxolane-4-Acetate is a high-value chiral synthon and protected form of (S)-(-)-Malic acid, serving as a critical building block in asymmetric synthesis. Its primary value lies in providing a stereochemically defined, reactive ester functionality for the controlled introduction of chiral centers into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), natural products, and specialty agrochemicals where optical purity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of various APIs, including antiviral and cardiovascular drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or building block in stereoselective reactions to construct complex molecular architectures.
• Natural Product Synthesis: Employed in the total synthesis of biologically active natural products requiring the (S)-malic acid moiety.
• Agrochemical Research: Serves as a starting material for developing chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Flavor & Fragrance Industry: Potential intermediate for the production of specific chiral flavor compounds.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and catalysis studies.

Basic Information

Product Name	Methyl (4S)-(+)-2,2-Dimethyl-1,3-Dioxolane-4-Acetate
CAS No.	95422-24-5
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	(4S)-2,2-Dimethyl-1,3-dioxolane-4-acetic acid methyl ester; Methyl (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-acetate; (S)-(-)-Malic acid dimethyl acetonide; (S)-(-)-Malic acid acetonide methyl ester; (4S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-acetic acid methyl ester; Methyl (S)-(-)-malate acetonide; (S)-Methyl malate acetonide
EINECS	Contact for details

Quality Control

Our Methyl (4S)-(+)-2,2-Dimethyl-1,3-Dioxolane-4-Acetate is produced under strict quality management systems to ensure batch-to-batch consistency and high optical purity. We provide comprehensive analytical data, including chiral HPLC or GC analysis to confirm enantiomeric excess (ee). A Certificate of Analysis (COA) detailing identity, purity, assay, and specific rotation is available for every batch upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed when not in use and stored away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 99.0% ee
Specific Rotation [α]20/D	+20° to +24° (c=1 in CHCl3)
Refractive Index n20/D	1.420 - 1.425
Density (g/mL, 20°C)	1.08 - 1.12

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.