Description

(3,4-Dichloro-Phenyl)-Trimethylsilanyloxy-Acetonitrile is a specialized organosilicon intermediate featuring a protected cyanohydrin moiety. This compound matters for its role as a versatile synthon in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those containing substituted phenyl and nitrile functionalities.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the dichlorophenyl group is a common bioactive motif.
• Material Science Research: Serves as a precursor for silicon-containing polymers or hybrid materials, leveraging the trimethylsilyl (TMS) protecting group.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes for the controlled introduction of the acetonitrile group under mild conditions.
• Ligand and Catalyst Development: Potential starting material for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	(3,4-Dichloro-Phenyl)-Trimethylsilanyloxy-Acetonitrile
CAS No.	95392-03-3
Molecular Formula	C11H13Cl2NOSi
Molecular Weight	274.22 g/mol
Synonyms	2-((3,4-Dichlorophenoxy)(trimethylsilyl)oxy)acetonitrile; (3,4-Dichlorophenoxy)(trimethylsilyl)acetonitrile; Trimethylsilyl (3,4-dichlorophenoxy)acetonitrile; O-Trimethylsilyl-3,4-dichlorophenoxyacetonitrile; 3,4-Dichlorophenoxy(trimethylsiloxy)acetonitrile; Acetonitrile, [(3,4-dichlorophenoxy)(trimethylsilyl)oxy]-; TMS-protected 3,4-dichlorophenoxyacetonitrile
EINECS	Contact for details

Quality Control

Our (3,4-Dichloro-Phenyl)-Trimethylsilanyloxy-Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.