Description

(-)-Benzylmethylphenylsilylacetic Acid is a high-purity, chiral organosilicon compound of significant interest in advanced synthetic chemistry. Its primary value lies in its utility as a versatile chiral building block and protecting group reagent, enabling the stereoselective synthesis of complex molecules. This product is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over molecular architecture.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce stereoselectivity in the formation of carbon-carbon and carbon-heteroatom bonds.
• Intermediate for Pharmaceutical Actives: Serves as a key precursor in the synthesis of chiral drug candidates, particularly those targeting central nervous system and metabolic disorders.
• Building Block for Specialty Ligands: Employed in the preparation of chiral ligands for catalysis, such as those used in asymmetric hydrogenation or cross-coupling reactions.
• Silyl Protecting Group Reagent: Provides a robust, chiral protecting group for carboxylic acids or alcohols in multi-step synthetic sequences.
• Agrochemical Intermediate: Used in the research and development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Investigated as a monomer or additive for creating chiral polymeric materials with specific optical properties.

Basic Information

Product Name	(-)-Benzylmethylphenylsilylacetic Acid
CAS No.	95373-54-9
Molecular Formula	C₁₆H₁₈O₂Si
Molecular Weight	270.40 g/mol
Synonyms	(S)-(-)-Benzylmethylphenylsilylacetic Acid; (S)-α-[(Benzylmethylphenylsilyl)]acetic Acid; (S)-BMPSA; (-)-BMPS-AA; 2-[(Benzylmethylphenylsilyl)]acetic Acid, (S)-; (S)-2-(Benzyl(methyl)(phenyl)silyl)acetic Acid; (S)-Carboxymethyl(benzyl)methylphenylsilane; (S)-Silicon-based Chiral Acid
EINECS	Contact for details

Quality Control

Our (-)-Benzylmethylphenylsilylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high enantiomeric purity and chemical identity, meeting the exacting standards required for research and process development. Certificates of Analysis (COA) detailing chiral purity (by chiral HPLC), chemical assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.