Description

L-Proline, 1-(Hydroxymethyl)-5-Oxo-, Methyl Ester (9Ci) is a specialized proline derivative, a key chiral building block in organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on producing peptides, enzyme inhibitors, and other advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapies.
• Peptide Chemistry: Used in the construction of modified peptide sequences where the proline scaffold influences secondary structure and biological activity.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Bioconjugation & Probe Development: Utilized in the design and synthesis of chemical probes and labeled compounds for biochemical and diagnostic research.
• Agrochemical Research: Acts as an intermediate in the development of advanced, bioactive agrochemicals with specific modes of action.

Basic Information

Product Name	L-Proline, 1-(Hydroxymethyl)-5-Oxo-, Methyl Ester (9Ci)
CAS No.	95083-42-4
Molecular Formula	C8H13NO4
Molecular Weight	187.19 g/mol
Synonyms	Methyl (2S)-1-(hydroxymethyl)-5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester, 1-hydroxymethyl-; 1-(Hydroxymethyl)-5-oxo-L-proline methyl ester; (S)-1-(Hydroxymethyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester; Methyl 1-(hydroxymethyl)-5-oxo-L-prolinate; 95083-42-4; Proline derivative, L-1-(hydroxymethyl)-5-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(Hydroxymethyl)-5-Oxo-, Methyl Ester (9Ci) is produced under strict quality management systems. We offer material suitable for research and development, with purity typically meeting or exceeding 97% (HPLC). Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring traceability and consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.