Description

Ethyl (3R,S)-2,2-Difluoro-3-Hydroxy-3-(2,2-Dimethyldioxolan-4-Yl)Propionate is a high-value chiral building block and fluorinated intermediate of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine atoms and protected diol functionality, which are critical for modulating the biological activity and metabolic stability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of fluorinated drug candidates, including potential antivirals, antibiotics, and CNS-active compounds.
• Agrochemical Synthesis: Used in constructing advanced fluorinated active ingredients for crop protection, where fluorine enhances lipophilicity and environmental stability.
• Advanced Material Precursor: Serves as a building block for specialty fluorinated polymers or liquid crystals with unique properties.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce complex, multi-functional chiral centers into target molecules.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of fluorinated fine chemicals.
• Academic & Institutional Research: A valuable reagent for methodological studies in organofluorine chemistry and synthetic methodology development.

Basic Information

Item	Details
Product Name	Ethyl (3R,S)-2,2-Difluoro-3-Hydroxy-3-(2,2-Dimethyldioxolan-4-Yl)Propionate
CAS No.	95058-92-7
Molecular Formula	C₁₀H₁₆F₂O₅
Molecular Weight	254.23 g/mol
Synonyms	Ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanoate; (3R,S)-Ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate; 95058-92-7; Difluorohydroxypropionate dioxolane derivative; Acetal-protected ethyl difluorohydroxypropionate; Ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)-propionate
EINECS	Contact for details

Quality Control

Our production of Ethyl (3R,S)-2,2-Difluoro-3-Hydroxy-3-(2,2-Dimethyldioxolan-4-Yl)Propionate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.