Description

Proline, 4-Fluoro-5-Oxo-, Methyl Ester, trans- (9Ci) is a high-value, fluorinated proline derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a fluorine atom and a keto-ester moiety, makes it an essential intermediate for constructing complex molecules with tailored biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, peptide mimetics, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptide-based therapeutic programs.
• Medicinal Chemistry: Used to introduce fluorine atoms and constrained proline scaffolds into lead compounds to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Serves as a building block for novel pesticides and herbicides, where the fluorine atom can enhance activity and environmental persistence.
• Peptidomimetics: Employed in the design and synthesis of peptide analogs to improve stability against enzymatic degradation.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological mechanisms and enzyme functions.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in catalytic asymmetric reactions to construct enantiomerically pure compounds.

Basic Information

Product Name	Proline, 4-Fluoro-5-Oxo-, Methyl Ester, trans- (9Ci)
CAS No.	95048-75-2
Molecular Formula	C7H10FNO3
Molecular Weight	175.16 g/mol
Synonyms	trans-4-Fluoro-5-oxoproline methyl ester; Methyl (2S,4R)-4-fluoro-5-oxopyrrolidine-2-carboxylate; 4-Fluoro-5-oxo-L-proline methyl ester; (4R)-4-Fluoro-5-oxo-L-proline methyl ester; 4-Fluoro-5-oxoproline methyl ester; L-Proline, 4-fluoro-5-oxo-, methyl ester, trans-; Fluoroproline derivative; 95048-75-2
EINECS	Contact for details

Quality Control

Every batch of Proline, 4-Fluoro-5-Oxo-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and chiral purity assays to ensure identity, potency, and chemical purity meet your specific research or development requirements. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.