Description

(E)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Butenoic Acid Ethyl Ester is a high-value, protected hydroxyl intermediate primarily used in advanced organic synthesis. This compound is critical for enabling complex multi-step reactions where selective protection and deprotection of functional groups are required. It is an essential building block for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected synthon for introducing specific chiral centers or functional groups into peptide chains.
• Natural Product Synthesis: Serves as a crucial intermediate in the total synthesis of complex natural products with biological activity.
• Asymmetric Synthesis: Employed in stereoselective reactions to construct molecules with defined three-dimensional configurations.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group provides robust protection for the hydroxyl moiety during synthetic sequences.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemical intermediates, and advanced materials.

Basic Information

Product Name	(E)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Butenoic Acid Ethyl Ester
CAS No.	94844-37-8
Molecular Formula	C12H24O3Si
Molecular Weight	244.41 g/mol
Synonyms	Ethyl (E)-4-[(tert-Butyldimethylsilyl)oxy]-2-butenoate; (E)-4-[(tert-Butyldimethylsilyl)oxy]-2-butenoic Acid Ethyl Ester; 4-[(tert-Butyldimethylsilyl)oxy]-2-butenoic Acid Ethyl Ester; TBDMS Protected 4-Hydroxy-2-butenoic Acid Ethyl Ester; Ethyl 4-(tert-Butyldimethylsiloxy)-2-butenoate; 4-(tert-Butyldimethylsilyloxy)-2-butenoic Acid Ethyl Ester; (E)-4-((tert-Butyldimethylsilyl)oxy)but-2-enoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our (E)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Butenoic Acid Ethyl Ester is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity, correct stereochemistry (E-isomer), and identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting cGMP and ISO standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E-isomer, GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.