Description

Tri-o-Acetyl-5-o-Trityl-D-Ribofuranose is a key protected ribofuranose derivative, a crucial chiral building block in organic synthesis. Its primary value lies in providing a selectively protected sugar scaffold for the controlled synthesis of nucleosides, nucleotides, and other bioactive molecules. This high-purity intermediate is essential for research and production in the pharmaceutical industry, particularly for antiviral and anticancer drug development.

Application

• Nucleoside/Nucleotide Synthesis: A critical protected intermediate for the controlled construction of ribose-containing nucleoside analogs.
• Antiviral Drug Development: Used in the research and production of active pharmaceutical ingredients (APIs) for antiviral medications.
• Anticancer Agent Research: Serves as a building block for novel chemotherapeutic compounds and prodrugs.
• Oligonucleotide Chemistry: Employed in the synthesis of modified oligonucleotides for therapeutic and diagnostic applications.
• Carbohydrate Chemistry: A versatile starting material for the synthesis of complex carbohydrates and glycoconjugates.
• Process Development & Scale-up: Used in pilot plants and commercial manufacturing for scalable, reproducible synthetic routes.

Basic Information

Product Name	Tri-o-Acetyl-5-o-Trityl-D-Ribofuranose
CAS No.	94482-37-8
Molecular Formula	C32H32O8
Molecular Weight	544.59 g/mol
Synonyms	1,2,3-Tri-O-acetyl-5-O-trityl-D-ribofuranose; 5-O-Trityl-1,2,3-tri-O-acetyl-D-ribofuranose; D-Ribofuranose, 5-O-trityl-, 1,2,3-triacetate; 1,2,3-Tri-O-acetyl-5-O-triphenylmethyl-D-ribofuranose; 5-O-Trityl-D-ribofuranose 1,2,3-triacetate; Protected D-Ribofuranose Derivative; Trityl-protected Ribose Triacetate
EINECS	Contact for details

Quality Control

Our Tri-o-Acetyl-5-o-Trityl-D-Ribofuranose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.