Description

5-Bromo-5-Deoxy-2,3-o-Isopropylidene-D-Ribonolactone is a high-purity, protected ribonolactone derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized sugar scaffold for constructing nucleoside analogs and other complex bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral agents, anticancer drugs, and novel molecular probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Antiviral Drug Development: Used in research and production of modified ribose derivatives for drugs targeting viral polymerases.
• Chemical Biology & Probe Synthesis: Acts as a versatile scaffold for creating labeled or modified sugars used in metabolic studies and target identification.
• Glycochemistry Research: Serves as a protected and activated intermediate for the synthesis of complex carbohydrates and glycomimetics.
• Process Chemistry & Scale-up: Suitable for GMP-compliant production processes requiring high chemical purity and consistent quality.
• Academic & Industrial R&D: Fundamental building block for exploring new chemical entities in medicinal chemistry programs.

Basic Information

Product Name	5-Bromo-5-Deoxy-2,3-o-Isopropylidene-D-Ribonolactone
CAS No.	94324-23-9
Molecular Formula	C9H11BrO4
Molecular Weight	263.09 g/mol
Synonyms	5-Bromo-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranuronic acid γ-lactone; 5-Bromo-5-deoxy-2,3-O-isopropylidene-D-ribono-1,4-lactone; 5-Bromo-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 1,4-lactone; 5-Bromo-5-deoxy-2,3-O-(1-methylethylidene)-D-ribono-1,4-lactone; 5-Bromo-2,3-O-isopropylidene-D-ribonolactone; 5-Bromo-5-deoxy-2,3-O-isopropylidene-D-ribono-γ-lactone
EINECS	Contact for details

Quality Control

Our 5-Bromo-5-Deoxy-2,3-o-Isopropylidene-D-Ribonolactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.