Description

Glycine, N,n-Bis(Phenylmethyl)-, 1,1-Dimethylethyl Ester is a protected amino acid derivative, specifically a tert-butyl ester of dibenzyl glycine, which serves as a crucial building block in advanced organic synthesis. Its primary value lies in providing a versatile and stable intermediate for the construction of complex peptides and pharmaceutical compounds, where selective deprotection strategies are required. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in developing new active pharmaceutical ingredients (APIs) and specialty molecules.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of peptide-based drugs and complex organic molecules targeting various therapeutic areas.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce glycine residues while protecting the amine and carboxylic acid functionalities from unwanted side reactions.
• API Development: Serves as a critical building block in research and development for novel Active Pharmaceutical Ingredients (APIs), enabling precise molecular architecture.
• Fine Chemical Synthesis: Employed in the preparation of specialty chemicals, catalysts, and ligands where a protected glycine moiety is required.
• Bioconjugation: Useful in the field of bioconjugation for linking peptides to other molecules, such as dyes, polymers, or drug delivery systems.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry and for exploring new synthetic pathways in R&D laboratories.

Basic Information

Product Name	Glycine, N,n-Bis(Phenylmethyl)-, 1,1-Dimethylethyl Ester
CAS No.	94226-56-9
Molecular Formula	C21H27NO2
Molecular Weight	325.45 g/mol
Synonyms	N,N-Dibenzylglycine tert-Butyl Ester; tert-Butyl N,N-Dibenzylglycinate; Dibenzylglycine tert-Butyl Ester; Glycine, N,N-bis(phenylmethyl)-, 1,1-dimethylethyl ester; N,N-Dibenzylglycine t-Butyl Ester; BOC-Glycine(Dibenzyl); (tert-Butoxycarbonyl)amino(dibenzyl)acetic Acid (protected form)
EINECS	Contact for details

Quality Control

Our Glycine, N,n-Bis(Phenylmethyl)-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.