Description

Ethyl (S)-α-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate Monohydrochloride is a high-purity, chemically defined intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters as a critical building block for the development of targeted therapeutic agents, particularly in oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for the production of novel active pharmaceutical ingredients (APIs) and for use in process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug molecules, particularly nitrogen mustard-based chemotherapeutic agents.
• Oncology Research & Development: Used in the discovery and development of new anti-cancer compounds targeting specific cellular pathways.
• Process Chemistry & Scale-Up: Employed in process optimization, route scouting, and pilot-scale manufacturing of experimental pharmaceuticals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API production.
• Bioconjugation Studies: Potential use in the synthesis of antibody-drug conjugates (ADCs) and other targeted drug delivery systems due to its reactive functional groups.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Ethyl (S)-α-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate Monohydrochloride
CAS No.	94213-26-0
Molecular Formula	C24H25Cl2N3O4 • HCl
Molecular Weight	515.84 g/mol
Synonyms	(S)-Ethyl 2-((4-(bis(2-chloroethyl)amino)benzyl)(1,3-dioxoisoindolin-2-yl)acetate hydrochloride; Ethyl (S)-2-((4-(Bis(2-chloroethyl)amino)benzyl)(1,3-dioxoisoindolin-2-yl)acetate HCl; L-(-)-Ethyl α-[[p-[bis(2-chloroethyl)amino]phenyl]methyl]-1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetate hydrochloride; 94213-26-0; A nitrogen mustard-isoindoline conjugate; Isoindoline-1,3-dione derivative hydrochloride salt
EINECS	Contact for details

Quality Control

Our Ethyl (S)-α-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate Monohydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.