Description

(E)-3-[6-[1-Hydroxy-3-Pyrrolidinyl-1-(p-Tolyl)Propyl]-2-Pyridyl]Acrylic Acid is a high-purity, non-racemic chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its complex molecular architecture, featuring a pyrrolidinyl group and an acrylic acid moiety, makes it a critical building block for constructing sophisticated active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel therapeutic agents, particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of proprietary drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapies.
• API Synthesis: Serves as a crucial precursor in multi-step synthetic routes for complex, high-value Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes during drug discovery.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce specific stereocenters into target molecules.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals for advanced material science and agrochemical research.
• Reference Standard: Serves as an analytical standard for quality control and method development in regulatory and analytical laboratories.

Basic Information

Product Name	(E)-3-[6-[1-Hydroxy-3-Pyrrolidinyl-1-(p-Tolyl)Propyl]-2-Pyridyl]Acrylic Acid
CAS No.	93962-64-2
Molecular Formula	C22H26N2O3
Molecular Weight	366.46 g/mol
Synonyms	(E)-3-[6-[1-Hydroxy-3-Pyrrolidinyl-1-(p-Tolyl)Propyl]-2-Pyridyl]Acrylic Acid; (E)-3-(6-((1-Hydroxy-3-(pyrrolidin-1-yl)-1-(p-tolyl)propyl)pyridin-2-yl)acrylic acid; 93962-64-2; (E)-3-(6-(1-Hydroxy-3-(1-pyrrolidinyl)-1-(4-methylphenyl)propyl)-2-pyridinyl)-2-propenoic Acid; (2E)-3-[6-[1-Hydroxy-3-(pyrrolidin-1-yl)-1-(4-methylphenyl)propyl]pyridin-2-yl]prop-2-enoic acid
EINECS	Contact for details

Quality Control

Our (E)-3-[6-[1-Hydroxy-3-Pyrrolidinyl-1-(p-Tolyl)Propyl]-2-Pyridyl]Acrylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.