Description

Ethyl α-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate is a high-purity, synthetically derived chemical intermediate of significant importance in advanced pharmaceutical research and development. Its complex molecular structure, featuring a nitrogen mustard moiety linked to a phthalimide derivative, makes it a critical building block for the synthesis of targeted therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel oncology and immunomodulatory treatments.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of experimental anti-cancer agents and targeted therapies.
• Oncology Research: Used in academic and industrial R&D for developing novel chemotherapeutic compounds and prodrugs.
• Bioconjugation Studies: Acts as a reactive handle for attaching cytotoxic payloads to antibodies, peptides, or other targeting molecules in ADC (Antibody-Drug Conjugate) research.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for potential active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Used in mechanistic studies to investigate DNA alkylation and cellular apoptosis pathways.

Basic Information

Product Name	Ethyl α-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate
CAS No.	93942-39-3
Molecular Formula	C23H24Cl2N2O4
Molecular Weight	463.35 g/mol
Synonyms	Ethyl 2-[[[4-[bis(2-chloroethyl)amino]phenyl]methyl]-1,3-dioxo-1H-isoindol-2-yl]acetate; 2-[[[4-[Bis(2-chloroethyl)amino]phenyl]methyl]-1,3-dioxo-1H-isoindol-2-yl]acetic Acid Ethyl Ester; 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-acetic Acid, α-[[4-[Bis(2-chloroethyl)amino]phenyl]methyl]-, Ethyl Ester; Ethyl 2-((4-(bis(2-chloroethyl)amino)benzyl)-1,3-dioxoisoindolin-2-yl)acetate; NSC 338947
EINECS	Contact for details

Quality Control

Our Ethyl α-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support compliance with REACH and other relevant global regulatory frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.