Description

6-Chloro-2-Cyano-3-Nitropyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique molecular architecture, featuring chloro, cyano, and nitro substituents on a pyridine core, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and advanced intermediates.

Application

The distinct reactivity profile of 6-Chloro-2-Cyano-3-Nitropyridine enables its use in several high-value synthetic pathways:

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used to construct pyridine-based herbicides, fungicides, and insecticides with enhanced activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts.
• Material Science Research: Employed in the development of organic electronic materials, such as non-linear optical (NLO) chromophores and conductive polymers.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and activity-based probes for studying biological systems.
• Cross-Coupling Reactions: The chloro substituent is amenable to palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for rapid molecular diversification.

Basic Information

Product Name	6-Chloro-2-Cyano-3-Nitropyridine
CAS No.	93683-65-9
Molecular Formula	C6H2ClN3O2
Molecular Weight	183.55 g/mol
Synonyms	2-Chloro-5-Cyano-3-Nitropyridine; 3-Nitro-6-Chloropicolinonitrile; 6-Chloro-3-Nitropicolinonitrile; 2-Cyano-6-Chloro-3-Nitropyridine; 3-Nitro-2-Chloro-5-Cyanopyridine; Picolinonitrile, 6-chloro-3-nitro-; 93683-65-9
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Cyano-3-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the high standards required for research and scale-up applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.