Description

(2R,4S)-Methyl 2-tert-Butyl-3-Formyloxazolidine-4-Carboxylate is a high-purity chiral oxazolidine derivative, serving as a critical chiral auxiliary and building block in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric purity in final products. This compound is essential for research and production in the pharmaceutical and fine chemical industries, where precise stereochemistry is paramount for drug efficacy and material properties.

Application

• Asymmetric Synthesis: As a versatile chiral auxiliary for the stereocontrolled formation of carbon-carbon and carbon-heteroatom bonds.
• Pharmaceutical Intermediates: Key building block in the synthesis of active pharmaceutical ingredients (APIs) requiring specific (2R,4S) stereochemistry.
• Peptidomimetics & Proline Derivatives: Used in the preparation of conformationally constrained peptide analogs and modified amino acids.
• Catalyst & Ligand Preparation: Serves as a precursor for chiral catalysts and ligands used in enantioselective catalysis.
• Agrochemical Synthesis: Intermediate in the production of chiral agrochemicals with targeted biological activity.
• Academic & Process R&D: A valuable reagent for methodological development and scale-up studies in organic chemistry.

Basic Information

Product Name	(2R,4S)-Methyl 2-tert-Butyl-3-Formyloxazolidine-4-Carboxylate
CAS No.	93250-91-0
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	Methyl (2R,4S)-2-tert-butyl-3-formyl-1,3-oxazolidine-4-carboxylate; (2R,4S)-2-(tert-Butyl)-3-formyl-4-(methoxycarbonyl)oxazolidine; (R,S)-Methyl 2-tert-butyl-3-formyloxazolidine-4-carboxylate; Chiral Oxazolidine Formyl Ester; Evans Oxazolidinone Derivative; N-Formyl Oxazolidine Carboxylate; tert-Butyl Oxazolidine Formate Methyl Ester
EINECS	Contact for details

Quality Control

Our (2R,4S)-Methyl 2-tert-Butyl-3-Formyloxazolidine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.