Description

2',3'-o-(Methoxymethylene)Uridine 5'-(4-Chlorophenyl)Phosphate is a chemically modified nucleoside derivative, specifically a protected uridine monophosphate analog, designed for advanced synthetic applications. This compound is a critical building block in the synthesis of oligonucleotides and nucleotide prodrugs, offering precise control over phosphorylation and protecting group strategies. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of antiviral agents, mRNA therapeutics, and other nucleotide-based pharmaceuticals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleotide analogs for antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Serves as a protected monomer for solid-phase or solution-phase synthesis of modified RNA strands.
• Prodrug Development: Used in the design of phosphate prodrugs (e.g., ProTide technology) to enhance the bioavailability of nucleoside therapeutics.
• Biochemical Research: A tool compound for studying enzyme kinetics, particularly those involving kinases and phosphorylases.
• Antiviral Agent Development: Integral to research programs targeting viruses like Hepatitis C (HCV) and other RNA viruses.
• Labeled Compound Synthesis: A starting point for incorporating isotopic labels (e.g., 13C, 15N) into nucleotides for metabolic tracing studies.

Basic Information

Item	Detail
Product Name	2',3'-o-(Methoxymethylene)Uridine 5'-(4-Chlorophenyl)Phosphate
CAS No.	93134-82-8
Molecular Formula	C17H19ClN2O9P
Molecular Weight	461.77 g/mol
Synonyms	Uridine, 2',3'-O-(methoxymethylene)-, 5'-(4-chlorophenyl) phosphate; 2',3'-O-Methoxymethylideneuridine 5'-(4-chlorophenyl) phosphate; 4-Chlorophenyl 2',3'-O-methoxymethylideneuridin-5'-yl phosphate; 5'-(4-Chlorophenyl)phosphate-2',3'-O-methoxymethyleneuridine; Protected Uridine Monophosphate; Nucleoside Phosphoramidate Precursor
EINECS	Contact for details

Quality Control

Our production of 2',3'-o-(Methoxymethylene)Uridine 5'-(4-Chlorophenyl)Phosphate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. We support development under quality systems aligned with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.