Description

tert-Butyldiphenylsilyl Trifluoromethanesulfonate is a highly reactive silylating agent and protecting group reagent used in advanced organic synthesis. Its primary value lies in its ability to introduce the robust tert-butyldiphenylsilyl (TBDPS) protecting group onto hydroxyl functionalities under mild conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries, where precise control over synthetic pathways is critical.

Application

• Protection of Hydroxyl Groups: Selective protection of primary and secondary alcohols in complex multi-step syntheses, particularly for carbohydrate and nucleoside chemistry.
• Pharmaceutical Intermediate Synthesis: A key reagent in the production of active pharmaceutical ingredients (APIs) and complex natural products.
• Oligonucleotide and Peptide Synthesis: Used to protect sugar hydroxyls during the solid-phase synthesis of oligonucleotides and sensitive amino acid side chains.
• Material Science Research: Employed in the surface functionalization of silicon-based materials and the synthesis of specialized silicone polymers.
• Asymmetric Synthesis: Utilized in chiral auxiliary and catalyst development where temporary protection is required.
• Agrochemical Manufacturing: Intermediate in the synthesis of advanced herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	tert-Butyldiphenylsilyl Trifluoromethanesulfonate
CAS No.	92886-86-7
Molecular Formula	C₁₇H₂₁F₃O₃SSi
Molecular Weight	390.50 g/mol
Synonyms	TBDPS Triflate; tert-Butylchlorodiphenylsilane Triflate; TBDPS-OTf; TBDPS Trifluoromethanesulfonate; Diphenyl-tert-butylsilyl Triflate; 2-Methyl-2-(trifluoromethanesulfonyloxy)-1,1-diphenylpropane; Silane, tert-butyldiphenyl-, trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our tert-Butyldiphenylsilyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.