Description

Ethyl 5-[Bis(2-Chloroethyl)Amino]-1H-Indole-3-Carboxylate is a specialized nitrogen mustard derivative of indole, a key heterocyclic scaffold in medicinal chemistry. This compound matters as a versatile and critical pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted anti-cancer and alkylating agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of experimental anti-cancer compounds and targeted therapies.
• Alkylating Agent Research: Serves as a core structure for developing novel nitrogen mustard-based chemotherapeutic agents.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies to optimize the efficacy and selectivity of indole-derived drug candidates.
• Bioconjugation & Prodrug Development: Employed in the design of antibody-drug conjugates (ADCs) and prodrugs for targeted drug delivery.
• Biochemical Tool Compound: Utilized in biochemical assays to study DNA alkylation mechanisms and cellular response pathways.
• Academic & Institutional Research: Supports fundamental research in oncology and chemical biology at universities and research institutes.

Basic Information

Product Name	Ethyl 5-[Bis(2-Chloroethyl)Amino]-1H-Indole-3-Carboxylate
CAS No.	92869-57-3
Molecular Formula	C15H18Cl2N2O2
Molecular Weight	329.22 g/mol
Synonyms	5-[Bis(2-chloroethyl)amino]-1H-indole-3-carboxylic acid ethyl ester; Ethyl 5-[bis(2-chloroethyl)amino]indole-3-carboxylate; 5-(N,N-Bis(2-chloroethyl)amino)indole-3-carboxylic acid ethyl ester; 1H-Indole-3-carboxylic acid, 5-[bis(2-chloroethyl)amino]-, ethyl ester; NSC 338947; Indole nitrogen mustard derivative
EINECS	Contact for details

Quality Control

Our Ethyl 5-[Bis(2-Chloroethyl)Amino]-1H-Indole-3-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.