Description

17-Ethynyl-16-Fluoroestradiol CAS NO 92817-14-6 is a high-purity, fluorinated derivative of estradiol, a key synthetic steroid intermediate. This compound is valued for its enhanced metabolic stability and receptor binding affinity, making it a critical building block in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing novel hormonal therapies, diagnostic agents, and radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel steroidal drugs and targeted hormonal therapies.
• Biomedical Research: Used as a reference standard and active compound in studies of estrogen receptor (ER) binding and function.
• Radiopharmaceutical Development: Serves as a backbone molecule for labeling with radioisotopes (e.g., Fluorine-18) for Positron Emission Tomography (PET) imaging agents.
• Endocrinology Studies: Employed in in vitro and in vivo research to investigate estrogenic activity and metabolic pathways.
• Chemical Synthesis: Used as a specialized fluorinated building block for creating more complex steroid analogs with modified biological profiles.

Basic Information

Product Name	17-Ethynyl-16-Fluoroestradiol
CAS No.	92817-14-6
Molecular Formula	C20H23FO2
Molecular Weight	314.40 g/mol
Synonyms	16-Fluoro-17-ethynylestra-1,3,5(10)-triene-3,17β-diol; 16-Fluoro-17α-ethynylestradiol; 17α-Ethynyl-16-fluoro-1,3,5(10)-estratriene-3,17β-diol; 16-Fluoro-EE2; 16-Fluoroethynylestradiol; 17-Ethynyl-16-fluoro-estradiol; 16-F-EE2
EINECS	Contact for details

Quality Control

Our 17-Ethynyl-16-Fluoroestradiol is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.