Description

16Alpha-Fluoro-17Beta-Estradiol is a fluorinated derivative of the natural estrogen hormone, 17β-estradiol. This structural modification enhances its metabolic stability and binding affinity, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel steroid-based therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced steroidal drugs and hormone therapies.
• Biochemical Research: Used as a reference standard and probe in studies of estrogen receptor (ER) binding and signaling pathways.
• Radiopharmaceutical Precursor: Serves as a precursor for the development of fluorine-18 (18F) labeled tracers for Positron Emission Tomography (PET) imaging.
• Development of Selective Estrogen Receptor Modulators (SERMs): Employed in the research and development of new SERMs with targeted tissue activity.
• Academic & Contract Research: Essential for universities and CROs conducting endocrinology, oncology, and metabolic disease research.

Basic Information

Product Name	16Alpha-Fluoro-17Beta-Estradiol
CAS No.	92817-10-2
Molecular Formula	C18H23FO2
Molecular Weight	290.37 g/mol
Synonyms	16α-Fluoroestradiol; 16α-Fluoro-17β-estradiol; 16-Fluoroestradiol; Estra-1,3,5(10)-triene-3,17β-diol, 16α-fluoro-; 16α-F-E2; NSC 112682; 16-Fluoro-17β-estradiol
EINECS	Contact for details

Quality Control

Our 16Alpha-Fluoro-17Beta-Estradiol is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.