Description

3-(tert-Butyldimethylsiloxy)Butanal is a valuable organosilicon-protected aldehyde intermediate used in advanced organic synthesis. This compound is crucial for its role as a protected form of 4-oxobutanal, enabling complex multi-step reactions where selective deprotection is required. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the production of active pharmaceutical ingredients (APIs), chiral building blocks, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those requiring selective aldehyde functionality.
• Chiral Synthesis: Used in the preparation of enantiomerically pure compounds for agrochemicals and advanced materials.
• Peptide Chemistry: Serves as a protected aldehyde component in the synthesis of peptide analogs and conjugates.
• Natural Product Synthesis: Employed in the total synthesis of natural products where sensitive aldehyde groups must be masked during other transformations.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Chemical Research: A versatile reagent in academic and industrial research for developing new synthetic methodologies.

Basic Information

Product Name	3-(tert-Butyldimethylsiloxy)Butanal
CAS No.	92775-37-6
Molecular Formula	C10H22O2Si
Molecular Weight	202.37 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]butanal; 4-(tert-Butyldimethylsiloxy)-2-butanone (common misnomer); 3-(TBDMSO)Butanal; 4-Oxobutanal tert-butyldimethylsilyl enol ether; Butanal, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS-protected 4-oxobutanal; 3-(tert-Butyldimethylsilyloxy)butyraldehyde
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsiloxy)Butanal is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.