Description

Ethyl 2,2-Difluoro-3-Hydroxy-3-Phenylpropanoate is a high-value fluorinated organic intermediate characterized by its difluoromethyl and β-hydroxy ester functionalities. This compound is crucial for the synthesis of complex molecules where the introduction of fluorine atoms can dramatically alter biological activity and physicochemical properties. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly protease inhibitors and other bioactive molecules where the difluoro group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging fluorine's ability to increase lipophilicity and target binding affinity.
• Material Science Research: Serves as a precursor for fluorinated monomers or additives to create polymers with specialized properties like chemical resistance, low surface energy, or unique optical characteristics.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecular architectures via reactions involving its ester and hydroxyl groups, such as esterifications, oxidations, and nucleophilic substitutions.

Basic Information

Item	Detail
Product Name	Ethyl 2,2-Difluoro-3-Hydroxy-3-Phenylpropanoate
CAS No.	92207-60-8
Molecular Formula	C11H12F2O3
Molecular Weight	230.21 g/mol
Synonyms	Ethyl 2,2-Difluoro-3-hydroxy-3-phenylpropionate; 3-Hydroxy-2,2-difluoro-3-phenylpropionic Acid Ethyl Ester; 2,2-Difluoro-3-hydroxy-3-phenylpropanoic Acid Ethyl Ester; Benzenepropanoic acid, β,β-difluoro-β-hydroxy-, ethyl ester; Ethyl β,β-difluoro-β-hydroxybenzenepropanoate; 92207-60-8; EFDPP (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2,2-Difluoro-3-Hydroxy-3-Phenylpropanoate is manufactured under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure the material meets your specific research or production requirements. Our quality systems are designed to support development from laboratory scale through to cGMP compliant production for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.