Description

Fotemustine CAS NO 92118-27-9 is a nitrosourea-based alkylating agent with significant antitumor activity. This compound is valued for its ability to cross the blood-brain barrier, making it a critical component in advanced oncological research and therapeutic development. It is primarily required by pharmaceutical R&D departments, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for the development of treatments targeting central nervous system malignancies and other solid tumors.

Application

• Oncological Pharmaceutical Research: Key intermediate in the synthesis of novel chemotherapeutic agents and targeted cancer therapies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as the core active component in the formulation of finished dosage forms for clinical use.
• Preclinical and Clinical Studies: Utilized in laboratory and trial settings to evaluate efficacy, pharmacokinetics, and safety profiles for new treatment protocols.
• Development of CNS Cancer Therapeutics: Specifically important for research into glioblastoma, brain metastases, and other central nervous system tumors due to its lipophilic properties.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Mechanistic Studies: Employed in biochemical research to investigate DNA alkylation mechanisms and cellular resistance pathways in cancer cells.

Basic Information

Product Name	Fotemustine
CAS No.	92118-27-9
Molecular Formula	C9H19ClN3O5P
Molecular Weight	315.69 g/mol
Synonyms	Fotemustin; S 10036; Diethyl 1-{1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl}phosphonate; Muphoran; (1-{1-[3-(2-Chloroethyl)-3-nitrosoureido]ethyl}phosphonic acid diethyl ester); NSC 648266; EUDRACODE 10036
EINECS	Contact for details

Quality Control

Our Fotemustine is manufactured and tested under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.