Description

(E)-4-(Trimethylsilyl)-2-Buten-1-Ol is a valuable organosilicon building block featuring a terminal hydroxyl group and a trimethylsilyl-protected alkenyl chain. This compound matters as a versatile intermediate for synthesizing complex molecules, particularly in the pharmaceutical and advanced materials sectors. It is primarily needed by R&D chemists and process development scientists for applications in organic synthesis, medicinal chemistry, and the creation of silicon-containing polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, especially those requiring silicon isosteres or specific olefin geometries.
• Organometallic Chemistry: Used as a ligand precursor or a substrate in cross-coupling reactions and other metal-catalyzed transformations.
• Polymer & Material Science: Serves as a monomer or co-monomer for the development of specialty silicones and functional polymers with tailored properties.
• Organic Synthesis Building Block: Employed in Horner-Wadsworth-Emmons or other olefination reactions to introduce the (E)-configured butenol moiety into target molecules.
• Agrochemical Research: Intermediate in the development of new active ingredients with improved efficacy and environmental profiles.
• Flavor & Fragrance Industry: Potential precursor for the synthesis of specific aroma chemicals and terpene analogs.

Basic Information

Product Name	(E)-4-(Trimethylsilyl)-2-Buten-1-Ol
CAS No.	92097-18-2
Molecular Formula	C7H16OSi
Molecular Weight	144.29 g/mol
Synonyms	(E)-4-(Trimethylsilyl)-2-buten-1-ol; 4-(Trimethylsilyl)-2-buten-1-ol, (E)-; (E)-4-(Trimethylsilyl)but-2-en-1-ol; 2-Buten-1-ol, 4-(trimethylsilyl)-, (E)-; (E)-4-(TMS)-2-buten-1-ol; trans-4-(Trimethylsilyl)-2-buten-1-ol; 4-Trimethylsilyl-2-buten-1-ol (E-isomer)
EINECS	Contact for details

Quality Control

Our (E)-4-(Trimethylsilyl)-2-Buten-1-Ol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial applications. Certificates of Analysis (COA) with detailed specifications from GC, HPLC, and NMR are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Isomeric Purity ((E)-isomer)	≥ 98.0% (by GC or HPLC)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.