Description

4-Benzoylbenzoic Acid Succinimidyl Ester is a high-purity, activated ester derivative primarily used as a versatile bioconjugation reagent. This compound is critical for creating stable amide bonds between carboxylic acid-containing molecules and primary amines under mild conditions, enabling precise chemical modification. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors who require reliable, high-quality crosslinkers for peptide synthesis, antibody-drug conjugate (ADC) development, and surface functionalization.

Application

• Bioconjugation & Crosslinking: Key reagent for coupling carboxylic acids to amines in peptides, proteins, and antibodies for ADC development and protein labeling.
• Pharmaceutical Intermediates: Serves as a critical synthon in the synthesis of targeted therapeutic agents and prodrugs.
• Diagnostic Reagents: Used in the preparation of enzyme conjugates, fluorescent probes, and other labeled biomolecules for immunoassays and biosensors.
• Polymer & Materials Science: Functionalizes surfaces and polymers by introducing benzophenone moieties for photo-crosslinking applications.
• Peptide Synthesis: An effective coupling agent in solid-phase and solution-phase peptide synthesis.
• Research & Development: A valuable tool in chemical biology for studying protein interactions and modifying biomolecules.

Basic Information

Product Name	4-Benzoylbenzoic Acid Succinimidyl Ester
CAS No.	91990-88-4
Molecular Formula	C18H13NO5
Molecular Weight	323.30 g/mol
Synonyms	N-Succinimidyl 4-Benzoylbenzoate; 4-Benzoyl-Benzoic Acid N-Hydroxysuccinimide Ester; NHS Ester of 4-Benzoylbenzoic Acid; 4-Benzoylbenzoyloxysuccinimide; BzBz-OSu; p-Benzoylbenzoyloxysuccinimide; 4-(Benzoyl)benzoic Acid Succinimidyl Ester; Succinimidyl 4-Benzoylbenzoate
EINECS	Contact for details

Quality Control

Every batch of our 4-Benzoylbenzoic Acid Succinimidyl Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive bioconjugation and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; desiccate and handle under inert atmosphere for long-term storage to maintain optimal reactivity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.