Description

(Z)-Ethyl-4,5-o-Isopropylidene-(S)-4,5-Dihydroxy-2-Pentenoate is a high-value chiral intermediate featuring a protected diol and an ethyl ester functionality. This compound is critical for its role in the stereoselective synthesis of complex bioactive molecules, offering precise control over molecular architecture. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing advanced therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of antiviral agents, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereocontrolled chemical reactions to construct molecules with defined three-dimensional structures.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of complex natural products with biological activity.
• Ligand and Catalyst Development: Used to create novel chiral ligands and organocatalysts for catalytic asymmetric transformations.
• Agrochemical Research: Employed in the development of new, enantiomerically pure pesticides and herbicides.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research.

Basic Information

Product Name	(Z)-Ethyl-4,5-o-Isopropylidene-(S)-4,5-Dihydroxy-2-Pentenoate
CAS No.	91926-90-8
Molecular Formula	C11H18O5
Molecular Weight	230.26 g/mol
Synonyms	Ethyl (4S,5S)-4,5-O-Isopropylidene-4,5-dihydroxy-2-pentenoate; (S,S)-Ethyl 4,5-O-Isopropylidene-4,5-dihydroxy-2-pentenoate; (Z)-Ethyl (4S,5S)-4,5-O-(1-Methylethylidene)-4,5-dihydroxy-2-pentenoate; (4S-cis)-4,5-O-(1-Methylethylidene)-4,5-dihydroxy-2-pentenoic Acid Ethyl Ester; Chiral Diol Ester Intermediate; Acetonide-Protected Dihydroxy Pentenoate Ester.
EINECS	Contact for details

Quality Control

Our (Z)-Ethyl-4,5-o-Isopropylidene-(S)-4,5-Dihydroxy-2-Pentenoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is stable under inert atmosphere. Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.