Description

n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-7-(Trifluoromethyl)Quinolin-4-Amine is a sophisticated nitrogen mustard derivative and a key advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of targeted therapeutic agents, particularly in oncology research. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers developing next-generation chemotherapeutic and alkylating agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel nitrogen mustard-based chemotherapeutic compounds.
• Oncology Research: Used in academic and industrial laboratories for developing targeted cancer therapies and studying alkylating agent mechanisms.
• Bioconjugation: Serves as a reactive moiety for attaching cytotoxic payloads to antibodies, peptides, or other targeting ligands in Antibody-Drug Conjugate (ADC) development.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce off-target toxicity.
• Preclinical Development: Supplied to CROs and biotech companies for in vitro and in vivo efficacy and toxicity studies.

Basic Information

Product Name	n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-7-(Trifluoromethyl)Quinolin-4-Amine
CAS No.	91919-63-0
Molecular Formula	C21H19Cl2F3N4
Molecular Weight	455.31 g/mol
Synonyms	7-(Trifluoromethyl)-N-[[[4-[bis(2-chloroethyl)amino]phenyl]methylene]amino]-4-quinolinamine; N-((4-(Bis(2-chloroethyl)amino)benzylidene)amino)-7-(trifluoromethyl)quinolin-4-amine; 4-Amino-7-trifluoromethylquinoline Schiff base of 4-bis(2-chloroethyl)aminobenzaldehyde; Nitrogen mustard quinoline derivative; Mustard-quinoline hybrid compound
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP guidelines where applicable for pharmaceutical development. Each batch undergoes comprehensive analytical characterization including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere if possible to maximize long-term stability. Handle and store in accordance with all applicable laboratory safety regulations.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.