Description

8-(tert-Butyldimethylsilanyloxy)-Octan-1-Ol is a bifunctional organosilicon compound featuring both a protected hydroxyl group and a terminal free alcohol. This molecular structure makes it a versatile and valuable intermediate in advanced organic synthesis, particularly for the controlled construction of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for applications requiring selective protection and functionalization.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring lipophilic side chains or spacer units.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group serves as a robust protecting group for alcohols, allowing for selective reactions at the terminal primary hydroxyl group.
• Linker Molecule: Used in the development of prodrugs, bioconjugates, and polymer-drug conjugates due to its dual functionality and defined chain length.
• Material Science Precursor: Intermediate in the synthesis of functionalized silanes, surfactants, or surface-modifying agents for specialty materials.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes to natural products, agrochemicals, and other complex organic targets.

Basic Information

Product Name	8-(tert-Butyldimethylsilanyloxy)-Octan-1-Ol
CAS No.	91898-32-7
Molecular Formula	C₁₄H₃₂O₂Si
Molecular Weight	260.50 g/mol
Synonyms	8-[(1,1-Dimethylethyl)dimethylsilyl]oxy-1-octanol; 8-[(tert-Butyl)dimethylsilyl]oxy-1-octanol; 8-(TBDMS-oxy)-1-octanol; 1-Octanol, 8-[(1,1-dimethylethyl)dimethylsilyl]oxy-; 8-Hydroxyoctyl tert-butyldimethylsilyl ether; 8-O-TBDMS-1-octanol; Octane-1,8-diol, 8-O-tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 8-(tert-Butyldimethylsilanyloxy)-Octan-1-Ol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by modern analytical techniques including NMR, GC, and HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.