Description

[1R,(-)]-6α-Acetyloxy-1,2,3,4,4Aα,5,6,8Aα-Octahydro-4α-Hydroxy-4,7-Dimethyl-α-Methylene-1α-Naphthaleneacetic Acid Methyl Ester is a high-purity, stereochemically defined intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral building block in the development of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within the fields of medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of proprietary drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold or precursor for constructing complex molecular libraries in drug discovery programs targeting various disease pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable, cost-effective manufacturing of target molecules.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce specific chiral centers, leveraging its defined [1R,(-)] configuration.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in related chemical processes.
• Academic Research: Used in university and institutional labs for studies in total synthesis, natural product chemistry, and reaction methodology.

Basic Information

Item	Detail
Product Name	[1R,(-)]-6α-Acetyloxy-1,2,3,4,4Aα,5,6,8Aα-Octahydro-4α-Hydroxy-4,7-Dimethyl-α-Methylene-1α-Naphthaleneacetic Acid Methyl Ester
CAS No.	91896-96-7
Molecular Formula	C19H28O5
Molecular Weight	336.42 g/mol
Synonyms	(-)-6α-Acetoxy-4α-hydroxy-4,7-dimethyl-α-methylene-1α-naphthaleneacetic acid methyl ester; Methyl (1R,4aR,6R,8aR)-6-acetoxy-4a-hydroxy-4,7-dimethyl-α-methylenedecahydronaphthalene-1-acetate; (1R,4aR,6R,8aR)-6-(Acetyloxy)-4a-hydroxy-4,7-dimethyl-α-methylenedecahydronaphthalene-1-acetic acid methyl ester; A chiral decalin derivative; A key intermediate for forskolin analogs; Light-sensitive decalin ester.
EINECS	Contact for details

Quality Control

Our [1R,(-)]-6α-Acetyloxy-1,2,3,4,4Aα,5,6,8Aα-Octahydro-4α-Hydroxy-4,7-Dimethyl-α-Methylene-1α-Naphthaleneacetic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.