Description

6-Carboxytetramethylrhodamine is a highly fluorescent, water-soluble derivative of the classic rhodamine dye family, widely recognized for its superior photostability and brightness. This compound is a critical building block for synthesizing active esters and other conjugates used in advanced labeling and detection technologies. It is essential for researchers and manufacturers in the life sciences, diagnostics, and biotechnology sectors who require reliable, high-performance fluorescent probes.

Application

• Fluorescent Labeling Reagent: Primary use as a precursor for synthesizing NHS esters and other reactive derivatives to label proteins, antibodies, peptides, and nucleic acids.
• Bioconjugation & Probe Synthesis: A key intermediate in the production of fluorescent probes for fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and flow cytometry.
• Diagnostic Assay Development: Used in the manufacturing of reagents for clinical diagnostics, including ELISA and lateral flow assays, due to its bright and stable emission.
• Cell Imaging & Microscopy: Enables the creation of conjugates for live-cell and fixed-cell imaging applications, providing excellent signal-to-noise ratios.
• Sensor & Device Fabrication: Incorporated into the design of chemical sensors and optoelectronic devices that utilize its fluorescent properties.

Basic Information

Product Name	6-Carboxytetramethylrhodamine
CAS No.	91809-67-5
Molecular Formula	C25H21N2O5Cl
Molecular Weight	464.90 g/mol
Synonyms	6-TAMRA; 6-Carboxy-tetramethylrhodamine; 6-TAMRA acid; Tetramethylrhodamine-6-carboxylic acid; 6-Carboxy-N,N,N',N'-tetramethylrhodamine; 6-Carboxy-TMR; TAMRA-6-COOH; Rhodamine 6G carboxylic acid analog
EINECS	Contact for details

Quality Control

Our 6-Carboxytetramethylrhodamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and diagnostic applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Dark red to purple powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Absorption (λmax)	~525-535 nm
Emission (λmax)	~555-565 nm
Loss on Drying	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.