Description

(4R,5S)-(+)-4-Methyl-5-Phenyl-1,3-Oxazolidine-2-Thione is a high-purity chiral oxazolidinethione derivative, a key building block in asymmetric synthesis. This compound matters for its role as a versatile chiral auxiliary and ligand, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients and catalysts.

Application

• Asymmetric Synthesis: Employed as a chiral auxiliary in stereoselective carbon-carbon bond-forming reactions, such as aldol and alkylation reactions.
• Pharmaceutical Intermediates: A critical precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Catalyst Ligand: Used to prepare chiral ligands for transition metal catalysts in enantioselective hydrogenation and other catalytic processes.
• Agrochemical Research: Serves as a building block for developing chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Process R&D: A valuable tool in academic laboratories and industrial process development for exploring new synthetic methodologies.
• Fine Chemical Production: Used in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	(4R,5S)-(+)-4-Methyl-5-Phenyl-1,3-Oxazolidine-2-Thione
CAS No.	91794-28-4
Molecular Formula	C10H11NOS
Molecular Weight	193.26 g/mol
Synonyms	(4R,5S)-4-Methyl-5-phenyl-2-thioxo-1,3-oxazolidine; (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinethione; (4R-cis)-4-Methyl-5-phenyl-2-oxazolidinethione; (4R,5S)-4-Methyl-5-phenyloxazolidine-2-thione; (+)-4-Methyl-5-phenyl-1,3-oxazolidine-2-thione; Evans Chiral Auxiliary derivative; Chiral oxazolidinethione
EINECS	Contact for details

Quality Control

Our (4R,5S)-(+)-4-Methyl-5-Phenyl-1,3-Oxazolidine-2-Thione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.