Description

3-(tert-Butyldimethylsilyl)Morphinone is a key protected intermediate in advanced organic synthesis, specifically designed for the development of complex pharmaceutical molecules. Its primary value lies in providing a stable, silyl-protected form of the morphinone core, which is crucial for precise, multi-step synthetic routes. This compound is essential for R&D and production chemists in the pharmaceutical and fine chemical industries, particularly those focused on opioid receptor research, analgesic development, and novel alkaloid derivatives.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel opioid analgesics and receptor modulators.
• Medicinal Chemistry Research: Used in the exploration of structure-activity relationships (SAR) for compounds targeting the central nervous system.
• Alkaloid Derivative Synthesis: Serves as a protected precursor for the semi-synthesis of complex morphine-based and related alkaloid structures.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under controlled conditions.
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	3-(tert-Butyldimethylsilyl)Morphinone
CAS No.	91265-75-7
Molecular Formula	C21H33NO3Si
Molecular Weight	375.58 g/mol
Synonyms	3-[(1,1-Dimethylethyl)dimethylsilyl]morphinone; 3-(Tert-butyldimethylsilyl)morphinone; Morphinone, 3-(tert-butyldimethylsilyl)-; TBDMS-Morphinone; 3-TBDMS-Morphinone; 3-O-(tert-Butyldimethylsilyl)morphinone; 3-(tert-Butyldimethylsilyloxy)morphinone (common misnomer for the silyl ether); N/A
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsilyl)Morphinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.