Description

3-(tert-Butyldimethylsilyl)Morphinone is a key, high-purity synthetic intermediate used in advanced pharmaceutical research and development. This compound is critical for the synthesis of complex molecules, particularly in the field of opioid receptor research and the development of novel analgesics. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of specialized opioid compounds and their analogs for pharmacological studies.
• Medicinal Chemistry Research: Used in the design and development of new chemical entities (NCEs) targeting central nervous system (CNS) receptors.
• Process Chemistry & Scale-Up: Serves as a protected intermediate in the optimization and pilot-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as an analytical standard in method development and quality control for related pharmaceutical substances.
• Academic & Institutional Research: Facilitates studies in organic synthesis, stereochemistry, and the structure-activity relationships (SAR) of morphinan derivatives.

Basic Information

Product Name	3-(tert-Butyldimethylsilyl)Morphinone
CAS No.	91265-70-2
Molecular Formula	C21H33NO2Si
Molecular Weight	359.58 g/mol
Synonyms	3-[(1,1-Dimethylethyl)dimethylsilyl]morphinone; 3-(Tert-butyldimethylsilyl)morphinone; 3-TBDMS Morphinone; Morphinone, 3-(tert-butyldimethylsilyl)-; 3-(tert-Butyldimethylsilyl)-5,6-didehydro-4,5-epoxy-17-methylmorphinan-6-one
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsilyl)Morphinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as identity, purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.