Description

Pyrrolidine-3-Carboxylic Acid tert-Butyl Ester is a versatile and high-purity chiral building block essential for modern pharmaceutical and fine chemical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel chemical entities. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of protease inhibitors, neurological agents, and other bioactive molecules.
• Peptidomimetics & Constrained Peptides: Used to introduce the pyrrolidine-3-carboxylic acid scaffold, mimicking natural amino acids to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or chiral auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and plant growth regulators with specific chiral configurations.
• Ligand & Catalyst Development: Useful for constructing novel chiral ligands and organocatalysts used in homogeneous catalysis.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	Pyrrolidine-3-Carboxylic Acid tert-Butyl Ester
CAS No.	91040-52-7
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	tert-Butyl 3-pyrrolidinecarboxylate; 3-(tert-Butoxycarbonyl)pyrrolidine; 1-Boc-3-pyrrolidinecarboxylic acid; Pyrrolidine-3-carboxylic acid 1,1-dimethylethyl ester; 3-Pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester; 1-Boc-pyrrolidine-3-carboxylic acid; (R/S)-1-Boc-3-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our Pyrrolidine-3-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiomerically pure grades)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.