Description

4-Methyl-2-Trimethylsilanyl-Oxazole is a specialized organosilicon-protected oxazole derivative, a key building block in advanced organic synthesis. Its value lies in the trimethylsilyl (TMS) group, which acts as a versatile protecting and directing group for sensitive heterocyclic systems, enabling complex multi-step reactions with high selectivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, particularly those containing oxazole or imidazole cores with specific substitution patterns.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the protected oxazole moiety is incorporated into the active molecule.
• Organometallic & Catalysis Research: Serves as a ligand precursor or a modifying agent in the development of novel catalytic systems and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers requiring specific heterocyclic functionalities.
• Peptide Mimetics & Bio-conjugation: The TMS-protected oxazole can be used to introduce stable heterocyclic structures that mimic peptide bonds or serve as linkers in bioconjugation chemistry.
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry, enabling new C-H functionalization and cross-coupling strategies.

Basic Information

Product Name	4-Methyl-2-Trimethylsilanyl-Oxazole
CAS No.	90892-93-6
Molecular Formula	C8H15NOSi
Molecular Weight	169.30 g/mol
Synonyms	2-(Trimethylsilyl)-4-methyloxazole; 4-Methyl-2-(trimethylsilyl)oxazole; 2-Trimethylsilyl-4-methyloxazole; Oxazole, 4-methyl-2-(trimethylsilyl)-; 4-Methyl-2-trimethylsilanyloxazole; TMS-4-methyloxazole; 4-Methyl-2-(trimethylsiloxy)oxazole (common misnomer); 90892-93-6
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-Trimethylsilanyl-Oxazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.