Description

3-Amino-2-Hydroxy-5-Trifluoromethylpyridine is a high-value pyridine derivative characterized by its trifluoromethyl and amino-hydroxy substitution pattern. This compound is a critical advanced intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorine-containing motifs for enhanced potency and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing and hydrogen-bonding capabilities.
• Chemical Biology Probes: Utilized to develop fluorescent tags or molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	3-Amino-2-Hydroxy-5-Trifluoromethylpyridine
CAS No.	90778-25-9
Molecular Formula	C6H5F3N2O
Molecular Weight	178.11 g/mol
Synonyms	5-(Trifluoromethyl)-2-pyridinol-3-amine; 3-Amino-5-(trifluoromethyl)pyridin-2-ol; 2-Hydroxy-5-trifluoromethyl-3-aminopyridine; 3-Amino-2-hydroxy-5-(trifluoromethyl)pyridine; 2-Pyridinol, 3-amino-5-(trifluoromethyl)-; 5-Trifluoromethyl-3-amino-2-hydroxypyridine
EINECS	Contact for details

Quality Control

Our 3-Amino-2-Hydroxy-5-Trifluoromethylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.