Description

9-Azabicyclo[4.2.1]Non-2-Ene-9-Carboxylicacid, 2-Acetyl-, 1,1-Dimethylethyl Ester, (1R)- (9Ci) is a sophisticated chiral bicyclic amine derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. Its unique bridged nitrogen-containing structure makes it a valuable scaffold for constructing complex molecules with high stereochemical control. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active ingredients, particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Asymmetric Synthesis: Employed as a building block for constructing enantiomerically pure compounds in medicinal chemistry and process development.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies involving bicyclic amine chemistry.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	9-Azabicyclo[4.2.1]Non-2-Ene-9-Carboxylicacid, 2-Acetyl-, 1,1-Dimethylethyl Ester, (1R)- (9Ci)
CAS No.	90741-53-0
Molecular Formula	C14H21NO3
Molecular Weight	251.32 g/mol
Synonyms	(1R)-2-Acetyl-9-azabicyclo[4.2.1]non-2-ene-9-carboxylic acid tert-butyl ester; tert-Butyl (1R)-2-acetyl-9-azabicyclo[4.2.1]non-2-ene-9-carboxylate; (1R)-2-Acetyl-9-azabicyclo[4.2.1]non-2-ene-9-carboxylic acid 1,1-dimethylethyl ester; 9-Azabicyclo[4.2.1]non-2-ene-9-carboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester, (1R)-; (R)-tert-Butyl 2-acetyl-9-azabicyclo[4.2.1]non-2-ene-9-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.