Description

2,2,2-Trifluoro-n-(5-Oxo-5,6,7,8-Tetrahydronaphthalen-2-Yl)Acetamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoroacetamide and tetrahydronaphthalenone structure. This compound matters for its critical role as a sophisticated building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and inflammatory pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where its precise chemical architecture enables the introduction of key fluorinated motifs to enhance drug metabolism and bioavailability.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research.
• API Development: Used in the research and development of Active Pharmaceutical Ingredients (APIs) for potential neurological and anti-inflammatory applications.
• Fluorinated Compound Synthesis: Acts as a versatile precursor for introducing the trifluoroacetamide group into more complex molecular architectures.
• Chemical Research: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) and metabolic stability in drug design.
• Process Chemistry: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2,2,2-Trifluoro-n-(5-Oxo-5,6,7,8-Tetrahydronaphthalen-2-Yl)Acetamide
CAS No.	90401-87-9
Molecular Formula	C₁₂H₁₀F₃NO₂
Molecular Weight	257.21 g/mol
Synonyms	2,2,2-Trifluoro-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide; N-(5-Oxo-5,6,7,8-tetrahydronaphthalen-2-yl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoroacetamide, N-(5-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)-; 5,6,7,8-Tetrahydro-5-oxo-2-naphthalenetrifluoroacetamide; 90401-87-9; TFTA; Trifluoroacetamide tetrahydronaphthalenone derivative
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(5-Oxo-5,6,7,8-Tetrahydronaphthalen-2-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.