Description

2-Chloro-3,6-Difluorobenzyl Bromide is a versatile and highly reactive halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and difluoro substituents on the aromatic ring, makes it an essential precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorobenzyl moiety imparts desired biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for creating biaryl and complex aromatic systems.
• Ligand and Catalyst Development: Employed in the preparation of novel phosphine ligands and organocatalysts for asymmetric synthesis.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	2-Chloro-3,6-Difluorobenzyl Bromide
CAS No.	90292-67-4
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-3,6-difluorobenzene; (2-Chloro-3,6-difluorophenyl)methyl Bromide; α-Bromo-2-chloro-3,6-difluorotoluene; 2-Chloro-3,6-difluoro(bromomethyl)benzene; 2-Chloro-α-bromo-3,6-difluorotoluene; Benzene, 1-(bromomethyl)-2-chloro-3,6-difluoro-; 3,6-Difluoro-2-chlorobenzyl Bromide
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,6-Difluorobenzyl Bromide is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.