Description

L-Serine, 1,1-Dimethylethyl Ester CAS NO 90048-49-0 is a protected amino acid derivative, specifically the tert-butyl ester of L-serine, which serves as a crucial building block in synthetic organic chemistry. This compound is valued for its role in facilitating complex peptide synthesis by protecting the carboxylic acid group, allowing for selective reactions on other functional sites. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex therapeutic peptides and protein-based drugs.
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods as a protected amino acid to prevent unwanted side reactions.
• Bioconjugation & Probe Development: Serves as a linker or spacer molecule in the creation of labeled peptides for diagnostic assays and biochemical research.
• Chemical Biology Research: Employed in the study of protein structure-function relationships and the development of enzyme inhibitors.
• Agrochemical Synthesis: Can be utilized as an intermediate in the production of certain chiral herbicides or plant growth regulators.
• Material Science: Potential use in the synthesis of specialized polymers or coatings with specific biocompatibility properties.

Basic Information

Product Name	L-Serine, 1,1-Dimethylethyl Ester
CAS No.	90048-49-0
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	L-Serine tert-butyl ester; (S)-2-Amino-3-hydroxypropanoic acid 1,1-dimethylethyl ester; tert-Butyl L-serinate; H-Ser-OtBu; Boc-Ser-OtBu (when N-protected); Fmoc-Ser(OtBu)-OH (common protected form for SPPS); L-Serine O-tert-butyl ester; (2S)-2-Amino-3-hydroxypropanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our L-Serine, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.