Description

N-(Trimethylsilyl)ethanesulfonamide is a specialized organosilicon reagent featuring a silyl-protected sulfonamide group. This compound is valued for its role as a versatile synthetic intermediate and protecting group in advanced organic synthesis, particularly for sensitive nitrogen functionalities. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing or protecting sulfonamide moieties.
• Peptide & Nucleotide Chemistry: Serves as a protecting group for amines during solid-phase and solution-phase synthesis of peptides and oligonucleotides.
• Agrochemical Synthesis: A key building block in the development of novel herbicides, fungicides, and insecticides with sulfonamide backbones.
• Material Science Precursor: Employed in the production of specialty silicones and silicon-containing polymers with tailored properties.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions to form carbon-nitrogen and carbon-sulfur bonds.
• Chemical Derivatization: Utilized in analytical chemistry for the derivatization of amines and other nucleophiles to enhance detection.

Basic Information

Product Name	N-(Trimethylsilyl)ethanesulfonamide
CAS No.	999-99-5
Molecular Formula	C5H15NO2SSi
Molecular Weight	181.34 g/mol
Synonyms	N-(Trimethylsilyl)ethanesulfonamide; Ethanesulfonamide, N-(trimethylsilyl)-; TES-SA; TMS-ESA; Trimethylsilyl Ethanesulfonamide; N-(TMS)ethanesulfonamide; 2-Trimethylsilylethanesulfonamide; N-(Trimethylsilyl)-2-aminoethanesulfonic acid sulfonamide derivative
EINECS	Contact for details

Quality Control

Our N-(Trimethylsilyl)ethanesulfonamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process-scale applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system adheres to cGMP principles where applicable, ensuring reliability for critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.