Description

N,n-Diethyl-1,1,1-Trimethylsilylamine is a specialized organosilicon amine compound, widely recognized as a versatile silylating agent and a key building block in advanced organic synthesis. Its primary value lies in its ability to introduce the trimethylsilyl (TMS) protecting group, effectively shielding reactive functional groups like alcohols and amines during complex multi-step reactions. This makes it an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protecting agent for hydroxyl and amino groups in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Serves as a key reagent in the manufacture of advanced pesticides and herbicides, where selective protection of functional groups is required.
• Silylation Reagent: Employed to derivatize compounds for gas chromatography (GC) and mass spectrometry (MS) analysis, improving volatility and detection.
• Polymer & Material Science: Acts as a monomer or modifying agent in the synthesis of silicon-containing polymers, resins, and advanced materials with tailored properties.
• Organic Synthesis Building Block: Utilized in the preparation of complex organic molecules, including natural products and fine chemicals, where moisture-sensitive reactions are performed.
• Catalyst & Ligand Preparation: Used in the synthesis of nitrogen-containing ligands and catalysts for homogeneous catalysis.

Basic Information

Product Name	N,n-Diethyl-1,1,1-Trimethylsilylamine
CAS No.	996-50-9
Molecular Formula	C7H19NSi
Molecular Weight	145.32 g/mol
Synonyms	N,N-Diethyl-1,1,1-trimethylsilylamine; Diethyl(trimethylsilyl)amine; (Diethylamino)trimethylsilane; Trimethylsilyldiethylamine; TMS-DEA; N,N-Diethyltrimethylsilylamine; N-(Trimethylsilyl)diethylamine; Diethyl(trimethylsilyl)amine
EINECS	213-630-7

Quality Control

Our N,n-Diethyl-1,1,1-Trimethylsilylamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC and NMR analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.