Description

Estra-1,3,5(10)-Triene-3,17-Diol (17Beta)-, 17-Benzoate is a high-purity steroid derivative, specifically the 17β-benzoate ester of estradiol. This compound is a critical pharmaceutical intermediate and reference standard for the synthesis and quality control of steroidal active pharmaceutical ingredients (APIs). It is essential for research and manufacturing organizations requiring precise chemical building blocks for hormone-related therapies, analytical method development, and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex steroidal drugs and hormone-based therapeutics.
• Reference Standard: Used in analytical laboratories for method validation, calibration, and quality control testing of estradiol and related compounds via HPLC, GC, or LC-MS.
• Biochemical Research: Employed in studies investigating estrogen receptor binding, metabolic pathways, and the development of novel endocrine modulators.
• API Manufacturing: Serves as a controlled starting material or intermediate in Good Manufacturing Practice (GMP) production environments for steroidal APIs.
• Impurity Profiling: Utilized as a known impurity or degradation product standard to monitor and control the purity of estradiol benzoate and similar finished drug products.

Basic Information

Product Name	Estra-1,3,5(10)-Triene-3,17-Diol (17Beta)-, 17-Benzoate
CAS No.	983-30-2
Molecular Formula	C25H28O3
Molecular Weight	376.49 g/mol
Synonyms	Estradiol 17-Benzoate; 17β-Estradiol 17-Benzoate; Estra-1,3,5(10)-triene-3,17β-diol 17-benzoate; 3,17β-Dihydroxyestra-1,3,5(10)-trien-17-yl benzoate; Benzoic acid 17β-hydroxyestra-1,3,5(10)-trien-3-yl ester; NSC 17591
EINECS	213-574-9

Quality Control

Our Estra-1,3,5(10)-Triene-3,17-Diol (17Beta)-, 17-Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification, assay, and impurity profiling, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), physical characteristics, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.