Description

Cyclopropanecarboxylic Acid, 2-Phenyl-, Ethyl Ester, (1R,2S)-Rel- is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its defined stereochemistry makes it a valuable building block for creating complex molecules with specific three-dimensional architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly where the cyclopropane moiety is required for biological activity.
• Asymmetric Synthesis: Used as a starting material or precursor in catalytic asymmetric reactions to construct enantiomerically enriched compounds.
• Ligand and Catalyst Development: Serves as a backbone for synthesizing novel chiral ligands and organocatalysts used in stereoselective transformations.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents and pesticides that require specific stereoisomers for efficacy.
• Material Science: Potential monomer or precursor for specialized polymers and advanced organic materials with unique properties.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic chemistry and process development in fine chemical manufacturing.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Phenyl-, Ethyl Ester, (1R,2S)-Rel-
CAS No.	946-38-3
Molecular Formula	C12H14O2
Molecular Weight	190.24 g/mol
Synonyms	rel-(1R,2S)-Ethyl 2-phenylcyclopropanecarboxylate; Ethyl (1R,2S)-rel-2-Phenylcyclopropanecarboxylate; (1R,2S)-rel-2-Phenylcyclopropanecarboxylic Acid Ethyl Ester; trans-Ethyl 2-phenylcyclopropanecarboxylate (rel); Ethyl trans-2-Phenylcyclopropanecarboxylate (rel); 2-Phenylcyclopropanecarboxylic Acid Ethyl Ester, trans- (rel); NSC 334153
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.