Description

L-Proline, 1-Methyl-, Ethyl Ester (8Ci,9Ci) CAS NO 936-14-1 is a high-purity, protected amino acid derivative, specifically an ethyl ester of a methyl-substituted proline. This compound is a critical chiral building block in organic synthesis, valued for its role in constructing complex molecular architectures with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, chiral catalysts, and advanced fine chemicals.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide drugs, protease inhibitors, and other bioactive molecules.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for enantioselective synthesis.
• Peptide Research: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Incorporated into peptides and peptidomimetics for studying protein-protein interactions and enzyme mechanisms.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products and specialty chemicals.
• Agrochemical Research: Potential intermediate in the development of chiral active ingredients for crop protection.

Basic Information

Product Name	L-Proline, 1-Methyl-, Ethyl Ester (8Ci,9Ci)
CAS No.	936-14-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Ethyl L-1-Methylpyrrolidine-2-carboxylate; (S)-1-Methylpyrrolidine-2-carboxylic Acid Ethyl Ester; L-1-Methylproline Ethyl Ester; 1-Methyl-L-proline Ethyl Ester; NSC 334365; Ethyl (2S)-1-methylpyrrolidine-2-carboxylate; (S)-(-)-1-Methyl-2-pyrrolidinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Methyl-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.