Description

1'-[(2-Oxo-2H-Chromen-3-Yl)Carbonyl]-1',3',5',6',7',8'-Hexahydrospiro[Cyclohexane-2,2'-Quinazoline]-4'-One is a sophisticated spirocyclic organic compound that combines chromenone and quinazoline pharmacophores, making it a valuable intermediate for advanced research and development. This high-purity building block is critical for medicinal chemists exploring novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring complex, multi-cyclic heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and protein-protein interactions in biological systems.
• High-Throughput Screening (HTS): Incorporated into diverse compound libraries to identify new hits with potential therapeutic activity.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery programs for global biotech and pharma clients.

Basic Information

Product Name	1'-[(2-Oxo-2H-Chromen-3-Yl)Carbonyl]-1',3',5',6',7',8'-Hexahydrospiro[Cyclohexane-2,2'-Quinazoline]-4'-One
CAS No.	898916-85-3
Molecular Formula	C24H22N2O4
Molecular Weight	402.45 g/mol
Synonyms	1'-[(2-Oxo-2H-chromen-3-yl)carbonyl]-1',3',5',6',7',8'-hexahydrospiro[cyclohexane-2,2'-quinazolin]-4'-one; Spiro[cyclohexane-2,2'-quinazoline]-4'-one, 1'-[(2-oxo-2H-chromen-3-yl)carbonyl]hexahydro-; 898916-85-3; Chromenone-quinazoline spirocyclic derivative; CAS 898916-85-3
EINECS	Contact for details

Quality Control

Our production of 1'-[(2-Oxo-2H-Chromen-3-Yl)Carbonyl]-1',3',5',6',7',8'-Hexahydrospiro[Cyclohexane-2,2'-Quinazoline]-4'-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for research reproducibility. The material is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.