Description

3'-Chloro-3-(2,3-Dimethylphenyl)-4'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its precise molecular architecture serves as a key building block. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D. The CAS number for this compound is 898792-95-5.

Application

This specialized intermediate is designed for high-value synthetic applications, primarily in the following areas:

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or anti-inflammatory pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a key starting material (KSM) or an advanced intermediate for scaling up API manufacturing processes under GMP conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3'-Chloro-3-(2,3-Dimethylphenyl)-4'-Fluoropropiophenone
CAS No.	898792-95-5
Molecular Formula	C₁₇H₁₆ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-(2,3-dimethylphenyl)propan-1-one; 3-(2,3-Dimethylphenyl)-1-(3-chloro-4-fluorophenyl)propan-1-one; 3'-Chloro-3-(2,3-dimethylphenyl)-4'-fluoropropiophenone; 898792-95-5; Propiophenone, 3'-chloro-3-(2,3-dimethylphenyl)-4'-fluoro-; 1-Propanone, 1-(3-chloro-4-fluorophenyl)-3-(2,3-dimethylphenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3-(2,3-Dimethylphenyl)-4'-Fluoropropiophenone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.