Description

Ethyl 4-[2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Phenyl]-4-Oxobutyrate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutic areas. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drug candidates, where precise molecular architecture and reliable supply are paramount.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of proprietary drug molecules, especially those targeting neurological pathways.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of compound libraries for high-throughput screening.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of complex APIs that require the specific spirocyclic moiety for biological activity.
• Contract Research and Manufacturing Services (CRAMS): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Preclinical and Clinical Trial Material Production: Provides the chemical foundation for producing batches of investigational new drugs required for regulatory studies.

Basic Information

Item	Details
Product Name	Ethyl 4-[2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Phenyl]-4-Oxobutyrate
CAS No.	898781-23-2
Molecular Formula	C22H31NO5
Molecular Weight	389.49 g/mol
Synonyms	Ethyl 4-oxo-4-[2-[[8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)]methyl]phenyl]butanoate; 898781-23-2; 4-[2-[(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]phenyl]-4-oxobutanoic acid ethyl ester; Butanoic acid, 4-[2-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]phenyl]-4-oxo-, ethyl ester; Ethyl 4-(2-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)phenyl)-4-oxobutanoate
EINECS	Contact for details

Quality Control

Our Ethyl 4-[2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Phenyl]-4-Oxobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.