Description

2,5-Dichloro-3'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process development and scale-up of new drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug molecules, especially those targeting neurological pathways.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its unique benzophenone and spirocyclic motifs.
• Research & Development (R&D): Critical for academic and industrial research programs focused on novel heterocyclic compounds and spiro-fused systems.
• Process Chemistry: Employed in route scouting and optimization for the scalable, GMP-compliant production of target APIs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	2,5-Dichloro-3'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone
CAS No.	898762-25-9
Molecular Formula	C23H25Cl2NO3
Molecular Weight	434.36 g/mol
Synonyms	2,5-Dichloro-3'-(8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzophenone; 2',5-Dichloro-3-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; Benzophenone, 2,5-dichloro-3'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-; 898762-25-9; 2,5-Dichloro-3'-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)benzophenone
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-3'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.