Description

4'-Bromo-3-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-3'-Fluorobenzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and benzophenone structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, custom synthesis providers, and fine chemical manufacturers requiring precise molecular building blocks for drug discovery and process development.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of new drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) during clinical trial material production.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized compounds under cGMP conditions.
• Reference Standard: Can be used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	4'-Bromo-3-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-3'-Fluorobenzophenone
CAS No.	898761-93-8
Molecular Formula	C21H21BrFNO3
Molecular Weight	434.30 g/mol
Synonyms	3'-Fluoro-4'-bromo-3-[(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]benzophenone; 4'-Bromo-3-[(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]-3'-fluorobenzophenone; 3-[(8-Methyl-1,4-dioxa-8-azaspiro[4.5]decanyl)]-4'-bromo-3'-fluorobenzophenone; Benzophenone, 4'-bromo-3-[(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]-3'-fluoro-; 898761-93-8; Spirocyclic Benzophenone Intermediate
EINECS	Contact for details

Quality Control

Our 4'-Bromo-3-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-3'-Fluorobenzophenone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.